The quantitative and qualitative state of equilibrium among various neurotransmitters—excitatory (like glutamate) and inhibitory (like GABA)—within specific neural circuits, which dictates overall brain function and excitability. Optimal balance is essential for mood stability, appropriate stress response termination, and efficient cognitive processing. Imbalances directly manifest as altered perception, energy, and regulatory control.
Origin
This term originates from psychopharmacology and clinical biochemistry, emphasizing the need for proportional concentrations of signaling agents. “Balance” implies not just adequate amounts but the correct ratio between opposing forces. It is the chemical foundation for neurological health.
Mechanism
The chemistry involves the synthesis from precursor molecules, vesicular loading, release upon action potential, and subsequent reuptake or enzymatic degradation. Hormones profoundly influence this chemistry; for example, fluctuations in sex steroids can alter the expression of transporters responsible for clearing serotonin or dopamine from the synapse. Maintaining adequate cofactor status supports the efficiency of the synthesizing enzymes.
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