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Neurotoxic Waste Clearance

Meaning

The essential biological process of eliminating harmful metabolic byproducts, protein aggregates, and exogenous toxins from the interstitial fluid of the brain and spinal cord. This waste removal is critical because the central nervous system lacks a traditional lymphatic system, relying instead on the specialized glymphatic pathway. Impairment of this clearance mechanism is strongly implicated in neurodegenerative diseases and cognitive decline.