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Neurosteroid System

Meaning

The Neurosteroid System encompasses a unique class of endogenous steroids synthesized locally within the brain and peripheral nervous system that rapidly and potently modulate neuronal excitability and synaptic function. These molecules are distinct from classic steroid hormones in that they act directly on cell-surface receptors rather than solely on nuclear receptors to regulate gene expression. They are critical for modulating stress response, mood, anxiety, and cognitive function, representing a fundamental mechanism of neuroendocrine-behavioral control.