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Neurosteroid Signaling

Meaning

Neurosteroid Signaling refers to the rapid, non-genomic communication pathways mediated by steroids that are synthesized de novo within the central and peripheral nervous systems, independent of classical endocrine glands. These locally produced steroids, such as allopregnanolone and dehydroepiandrosterone (DHEA), act as potent modulators of neurotransmitter receptors and neural excitability. This unique signaling mechanism allows for the immediate, localized adjustment of nervous system function, impacting mood, anxiety, stress response, and memory formation. Understanding neurosteroid signaling provides a direct target for interventions aimed at stabilizing the nervous system and improving psychological well-being.