What is the Origin of Neurosteroid Signaling Integrity?

The concept arose from the discovery that certain steroids are locally produced in the brain, functioning as paracrine and autocrine modulators of neural circuits. The term 'integrity' emphasizes the functional coherence of this localized signaling system.

What is the Mechanism of Neurosteroid Signaling Integrity?

Neurosteroids often function as potent allosteric modulators of neurotransmitter receptors, particularly the GABA-A receptor, enhancing inhibitory signaling and promoting anxiolytic and sedative effects. Maintaining signaling integrity ensures the brain's intrinsic capacity to buffer stress and regulate its own excitability, supporting overall neuroendocrine resilience.

Neurosteroid Signaling Integrity

Meaning

The state of optimal synthesis, concentration, and receptor interaction of neurosteroids—steroid molecules synthesized de novo in the central and peripheral nervous systems, such as allopregnanolone and DHEA. This integrity is vital for modulating neuronal excitability, mood, and stress response, independent of peripheral endocrine glands. It is a marker of robust intrinsic brain health.