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Neurosteroid Safety

Meaning

Neurosteroid Safety is a clinical and pharmacological consideration focused on the therapeutic window and potential adverse effects of neurosteroids, which are steroid molecules synthesized de novo within the central and peripheral nervous systems, independent of the classical endocrine glands. These molecules, such as allopregnanolone and dehydroepiandrosterone (DHEA), rapidly modulate neuronal excitability by acting on neurotransmitter receptors like the GABA-A receptor. Assessing neurosteroid safety involves evaluating the risk of central nervous system side effects, including sedation, mood changes, and potential for abuse, especially when these compounds are administered exogenously as therapeutic agents for conditions like depression or anxiety.