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Neurosteroid Recalibration

Meaning

Neurosteroid Recalibration is a clinical and physiological strategy focused on modulating the local synthesis, metabolism, and receptor activity of neurosteroids, which are steroid hormones synthesized de novo within the nervous system itself, independent of peripheral endocrine glands. These molecules, such as allopregnanolone and DHEA, are critical modulators of various neurotransmitter receptors and local brain function, profoundly influencing mood, stress response, and cognition. Recalibration aims to restore and maintain optimal neurosteroid levels to enhance neurological and emotional resilience against chronic stress.