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Neurosteroid Production Decline

Meaning

Neurosteroid Production Decline is the age-related reduction in the de novo synthesis of steroid hormones within the central nervous system, independent of peripheral endocrine gland output. Neurosteroids, such as allopregnanolone and DHEA, are critical for modulating neurotransmitter activity, supporting mood regulation, enhancing memory, and promoting neurogenesis. This decline compromises the brain’s local homeostatic mechanisms, contributing to age-associated cognitive impairment, increased anxiety, and vulnerability to neurological disorders. Addressing this deficit is a key strategy in neuroendocrine-focused anti-aging protocols.