Skip to main content

Neurosteroid Function

Meaning

Neurosteroid function refers to the biological actions of steroid molecules that are synthesized de novo within the central and peripheral nervous systems, independent of classical endocrine gland production. These steroids, such as allopregnanolone and DHEA, act locally to modulate neuronal excitability, mood, and cognitive processes. Unlike peripheral hormones, neurosteroids rapidly influence brain function by acting as allosteric modulators of ligand-gated ion channels, notably the GABAA receptor. Their role is critical for maintaining neuro-hormonal balance and stress adaptation.