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Neurosteroid DHEA

Meaning

The specific classification of the steroid hormone dehydroepiandrosterone (DHEA) when it is synthesized de novo within the central nervous system by glial cells and neurons, rather than being solely derived from the adrenal glands. This locally produced DHEA functions as a neurosteroid, modulating neuronal excitability, enhancing synaptic plasticity, and providing essential neuroprotection against various insults. Its concentration in the brain can be distinct from circulating levels, highlighting its critical role in autonomous neural regulation.