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Neurosteroid Deficiency

Meaning

Neurosteroid Deficiency refers to a state characterized by sub-optimal concentrations of steroids synthesized de novo within the central and peripheral nervous systems, independent of the classical endocrine glands. These locally produced steroids, such as DHEA, pregnenolone, and their derivatives, act as crucial modulators of neuronal excitability, mood, memory, and stress response. A deficiency in these compounds is clinically associated with impaired cognitive function, mood disturbances, and reduced neuroprotection against excitotoxicity. Addressing this deficiency is a direct strategy for enhancing brain health and mental well-being.