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Neurosteroid Conversion

Meaning

Neurosteroid conversion is the enzymatic process by which precursor steroids, either circulating hormones or locally synthesized intermediates, are transformed into neuroactive steroids directly within the central and peripheral nervous systems. This localized metabolic activity is independent of the endocrine glands and is critical for rapidly modulating neuronal excitability, mood, and cognitive function. Key neurosteroids, such as allopregnanolone, are synthesized in glial cells and neurons, acting as potent modulators of neurotransmitter receptors. This tissue-specific conversion allows the brain to finely tune its hormonal environment separate from systemic endocrine fluctuations.