What is the Origin of Neurosteroid Concentration?

This concept arose from discoveries showing that neural tissue possesses the enzymatic machinery to synthesize steroids like allopregnanolone from cholesterol precursors. The term distinguishes these locally active steroids from those produced by classical endocrine glands.

What is the Mechanism of Neurosteroid Concentration?

Local synthesis is regulated by neuronal activity and specific glial cell signaling, bypassing the typical HPA or HPG axis control. These neurosteroids rapidly diffuse to adjacent synapses where they can allosterically modulate ion channels or bind to nuclear receptors, exerting immediate, localized effects on neuronal excitability.

Neurosteroid Concentration ∞ Area

Neurosteroid Concentration

Meaning

The local concentration of steroid hormones synthesized de novo within the central or peripheral nervous system, distinct from systemic circulating levels, which act as direct neuromodulators or neurotrophic factors. Measuring this concentration reflects the local biochemical environment supporting neuronal health and plasticity. It is a measure of intrinsic brain hormonal support.