What is the Origin of Neurosteroid Availability?

This concept stems from neuroendocrinology, identifying allopregnanolone and DHEA-S as critical, locally active signaling molecules.

What is the Mechanism of Neurosteroid Availability?

Availability dictates the degree to which these neurosteroids can allosterically modulate GABA-A receptors or act as ligands for nuclear receptors, thereby influencing neuronal excitability and mood stabilization.

Neurosteroid Availability

Meaning

Neurosteroid Availability describes the concentration of endogenous steroids, synthesized within the brain or periphery, that act as direct modulators of neuronal function.