Neurorestorative Compounds are therapeutic agents, either synthetic or naturally derived, specifically designed to facilitate the repair, regeneration, or functional recovery of damaged or degenerating neural circuits and cells within the central and peripheral nervous systems. The clinical goal is to actively rebuild lost neuronal structure and function, moving beyond mere symptom management or damage prevention. These compounds represent the cutting edge of regenerative neuroendocrinology.
Origin
A term from regenerative medicine and neuropharmacology, combining ‘neurorestorative’ (the ability to restore or repair nervous tissue) with ‘compounds’ (substances composed of two or more elements). It signifies a class of agents focused on active repair.
Mechanism
These compounds typically operate by stimulating endogenous repair processes, such as promoting neurogenesis in the hippocampus, enhancing synaptogenesis, and encouraging the remyelination of damaged axons. Their mechanism often involves the upregulation of key growth factors, like Vascular Endothelial Growth Factor (VEGF) and BDNF, or the modulation of stem cell pathways to recruit and differentiate progenitor cells into functional neurons and glia, effectively rebuilding the neural architecture.
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