Neuroprotective supplements are a class of nutraceutical agents and specific micronutrients administered with the clinical intent of reducing neuronal damage, slowing neurodegeneration, and maintaining the structural and functional integrity of the nervous system. These agents are selected based on their established capacity to cross the blood-brain barrier and exert measurable effects on cerebral physiology. They are integral to proactive brain health and longevity protocols.
Origin
The concept stems from the confluence of nutritional science, pharmacology, and gerontology, where the term “supplement” evolved from basic nutritional support to targeted therapeutic agents. The term “neuroprotective” was adopted to specifically categorize compounds whose primary biological action is safeguarding neuronal health against various stressors.
Mechanism
These supplements operate through diverse biochemical pathways, including enhancing mitochondrial bioenergetics, augmenting endogenous antioxidant defenses, and modulating inflammatory signaling within the central nervous system. Specific agents may also support the synthesis of essential neurotransmitters or promote the clearance of pathological protein aggregates. The fundamental mechanism is reducing oxidative stress and improving cellular resilience to metabolic and environmental challenges.
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