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Neuroprotective Steroid Signaling

Meaning

Neuroprotective Steroid Signaling describes the protective actions exerted by endogenous neurosteroids, such as allopregnanolone and DHEA, on neural tissue against excitotoxicity, oxidative stress, and ischemia. These steroids act rapidly, often via membrane receptors, to stabilize neuronal membranes and support mitochondrial health within the brain. This signaling is vital for mitigating acute injury and supporting long-term neuronal survival. We aim to optimize these intrinsic defense mechanisms.