The beneficial actions of certain neurosteroids, often metabolites of gonadal or adrenal hormones, that shield neuronal structures from excitotoxicity, oxidative stress, and ischemic damage.
Origin
This area of study emerged from understanding the pleiotropic actions of steroids beyond their classical endocrine roles, particularly their rapid effects within the brain.
Mechanism
These steroids exert effects by modulating GABA-A receptor activity, influencing neuronal membrane stability, and promoting anti-apoptotic signaling cascades within vulnerable neural populations.
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