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Neuroprotective Steroid Balance

Meaning

Neuroprotective Steroid Balance refers to the optimal ratio and concentration of endogenous neurosteroids, such as allopregnanolone and DHEA, within the central nervous system that promotes neuronal survival, synaptic plasticity, and resilience against neurodegenerative processes. These steroids are synthesized de novo in the brain and act as potent modulators of neurotransmitter receptors, particularly GABA and NMDA receptors. Maintaining this balance is essential for cognitive longevity, mood regulation, and protecting brain structure from the damaging effects of chronic stress and aging. A favorable balance is a key clinical biomarker of robust brain health and functional integrity.