Neuroprotective Hormone Therapy is a specialized clinical approach utilizing specific hormones, often bioidentical, at physiological or optimized doses to actively shield neurons from damage, slow neurodegeneration, and support brain structure and function. This therapy recognizes the critical role of endogenous hormones, such as progesterone, estrogen, and testosterone, as neurosteroids that modulate synaptic plasticity, reduce oxidative stress, and regulate inflammatory responses in the central nervous system. The goal is to preserve cognitive reserve and reduce the risk of age-related neurological decline.
Origin
This concept emerged from extensive research demonstrating that many peripheral hormones are also synthesized in the brain and possess direct neuroactive and neuroprotective properties. The term synthesizes “neuroprotective,” meaning safeguarding nerve tissue, with “Hormone Therapy,” the clinical intervention. Its foundation lies in observations of cognitive decline and increased neurodegenerative risk correlating with age-related hormone deficiencies.
Mechanism
The mechanism involves the hormones binding to specific receptors located on neuronal and glial cells, triggering anti-apoptotic and anti-inflammatory signaling cascades. For instance, progesterone can enhance myelination and reduce edema following injury, while estrogens support cerebral blood flow and synaptic density. By maintaining optimal levels of these neuroprotective steroids, the therapy helps stabilize the blood-brain barrier and foster a biochemical environment conducive to neuronal survival and repair.
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