What is the Origin of Neuroprotective Effects Testosterone?

This concept stems from neuroendocrinology research, which has elucidated the presence of androgen receptors and the local metabolism of testosterone within various brain regions, establishing its role as a vital neurosteroid. It recognizes the brain as a primary target tissue for androgens.

What is the Mechanism of Neuroprotective Effects Testosterone?

Testosterone exerts its protection by modulating gene expression through nuclear androgen receptors, activating rapid, non-genomic signaling pathways at the cell membrane, and serving as a substrate for aromatization into estrogen, which is a potent neuroprotectant. These combined actions promote neuronal survival, enhance synaptic plasticity, and regulate the synthesis of essential neurotrophins, maintaining a healthy neural environment.

Neuroprotective Effects Testosterone

Meaning

Neuroprotective Effects Testosterone refers to the specific biological actions of the androgen testosterone, and its neuroactive metabolites like dihydrotestosterone and estrogen, that actively safeguard neurons from injury, mitigate oxidative stress, reduce neuroinflammation, and support the structural and functional integrity of the central and peripheral nervous systems. These effects are crucial for maintaining cognitive health, mood regulation, and preventing neurodegenerative processes.