What is the Origin of Neuroprotective Effects of Androgens?

While androgens were historically linked primarily to reproductive function, research in neuroendocrinology has revealed their significant role in brain health. The recognition of androgen receptors in various brain regions, coupled with epidemiological data, established the foundation for this neuroprotective concept.

What is the Mechanism of Neuroprotective Effects of Androgens?

Androgens exert their protective influence through several pathways, including genomic effects via the Androgen Receptor (AR) to promote the expression of anti-apoptotic and growth-promoting genes. They also act via non-genomic mechanisms, such as modulating calcium channels and activating signaling kinases, to rapidly stabilize cell membranes and reduce inflammation. Furthermore, androgens can be metabolized into estrogens within the brain, which also possess potent neuroprotective properties.

Neuroprotective Effects of Androgens ∞ Area

Neuroprotective Effects of Androgens

Meaning

Neuroprotective Effects of Androgens describe the beneficial actions of testosterone, dihydrotestosterone (DHT), and other male sex hormones in preserving the structure, function, and viability of neurons and glial cells within the central and peripheral nervous systems. These effects extend beyond mere maintenance to include active defense against oxidative stress, excitotoxicity, and the pathological processes associated with neurodegenerative diseases. This mechanism is crucial for maintaining cognitive health and preventing age-related decline.