What is the Meaning of Neuroprotective Agents?

Neuroprotective Agents are pharmacological or endogenous compounds that actively shield neurons and glial cells from various forms of acute or chronic insults, including oxidative stress, excitotoxicity, and ischemic injury. In the context of wellness, these agents support the long-term structural and functional integrity of the central nervous system, crucial for maintaining cognitive performance and resilience against neurodegeneration. They stabilize cellular membranes and modulate inflammatory cascades within the CNS.

What is the Origin of Neuroprotective Agents?

The term combines 'Neuro,' referring to the nervous system structures, with 'Protective Agents,' signifying substances designed to defend against harm. Its modern relevance is amplified by research into mitigating the effects of chronic stress and metabolic syndrome on neuronal health.

What is the Mechanism of Neuroprotective Agents?

The mechanism of action varies but often involves enhancing endogenous antioxidant defenses, such as increasing glutathione levels, or stabilizing mitochondrial function within neurons to prevent the cascade leading to apoptosis. Some agents modulate inflammatory cytokines, reducing microglial activation that contributes to chronic neuroinflammation. Maintaining optimal thyroid hormone balance and adequate steroid hormone levels also acts as a fundamental, system-wide neuroprotective mechanism.

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