What is the Meaning of Neuroprotection?

Neuroprotection is a strategy encompassing mechanisms and treatments designed to safeguard the central and peripheral nervous systems from cellular damage, dysfunction, and subsequent degeneration. The goal is to preserve neuronal structure and function in the face of acute insults or chronic age-related processes. Effective neuroprotection is a key therapeutic aim in conditions ranging from neurodegenerative diseases to hormonal aging.

What is the Origin of Neuroprotection?

The term is a compound of "neuro," referring to the nervous system, and "protection," signifying defense or shielding. This concept gained clinical and research prominence as understanding of the vulnerability of neurons to oxidative stress and excitotoxicity grew. It represents a preventative and therapeutic paradigm shift in neurological medicine.

What is the Mechanism of Neuroprotection?

Neuroprotection is achieved through several physiological pathways, including the reduction of oxidative stress, the mitigation of chronic neuroinflammation, and the regulation of apoptotic pathways. Hormones, notably estrogens and anrdogens, exert powerful neuroprotective effects by promoting the release of neurotrophic factors and stabilizing mitochondrial function. The overall mechanism involves bolstering the neuron's intrinsic defense systems and maintaining the integrity of the blood-brain barrier.

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