What is the Origin of Neuroprotection via Steroids?

This concept emerged from neuroscience research demonstrating that steroid hormones, traditionally viewed as reproductive or metabolic regulators, also act as potent neurosteroids within the brain. The protective roles of estrogen, progesterone, and androgens against neurodegenerative processes are well-documented.

What is the Mechanism of Neuroprotection via Steroids?

The neuroprotective mechanism is multifaceted, involving both rapid, non-genomic actions through membrane receptors and slower, genomic effects via intracellular receptors. Steroids reduce oxidative stress by enhancing antioxidant enzyme activity and directly suppressing the release of pro-inflammatory cytokines from glial cells. They also promote the synthesis of myelin and neurotrophic factors, supporting structural and functional neuronal maintenance.

Neuroprotection via Steroids

Meaning

The therapeutic utilization of specific steroid hormones, both gonadal and adrenal, to prevent or mitigate damage to neurons and glial cells within the central nervous system. This protective effect is a non-genomic and genomic action of steroids that supports neuronal survival, synaptic integrity, and reduces neuroinflammation. It is a critical component of maintaining cognitive function and mood stability, especially during hormonal transitions or aging.