What is the Origin of Neuroprotection via Androgens?

This concept arises from combining "neuroprotection," the safeguarding of neural structures, with "androgens," the class of steroid hormones. Research in neuroscience has increasingly identified steroid receptors within glial cells and neurons, demonstrating their direct modulatory roles beyond traditional reproductive functions. It highlights a non-classical yet vital role for these hormones.

What is the Mechanism of Neuroprotection via Androgens?

Androgens exert neuroprotection through several mechanisms, including stabilizing mitochondrial function within neurons, thereby preventing the energy failure associated with excitotoxicity. Furthermore, they can modulate the expression of anti-apoptotic genes and reduce inflammatory cytokine production within the central nervous system. Testosterone's ability to interact with neuronal androgen receptors initiates cascades that enhance synaptic plasticity and cellular survival signaling pathways.

Neuroprotection via Androgens

Meaning

Neuroprotection via Androgens refers to the capacity of androgenic hormones, notably testosterone, to shield neuronal tissues from various forms of injury, including excitotoxicity, oxidative stress, and ischemic damage. This protective effect is clinically relevant in conditions affecting the central and peripheral nervous systems, supporting neuronal integrity. These steroids modulate cellular resilience within the delicate neural environment.