What is the Origin of Neuroprotection through Hormones?

This concept arises from neurobiology and endocrinology research, particularly studies investigating the role of sex steroids (like estradiol and testosterone) and thyroid hormones in brain health maintenance and recovery post-injury. It acknowledges hormones as signaling molecules with direct trophic effects on neural tissue.

What is the Mechanism of Neuroprotection through Hormones?

Hormones exert neuroprotection through several molecular routes, including enhancing synaptic plasticity via increased neurotrophin expression, such as BDNF, and modulating intracellular calcium buffering mechanisms. Additionally, certain hormones can directly interact with cellular membranes or mitigate the downstream inflammatory cascades initiated by neural injury, promoting survival signaling pathways.

Neuroprotection through Hormones

Meaning

The physiological capacity of specific steroid and peptide hormones to shield neuronal tissue from various insults, including excitotoxicity, oxidative stress, inflammation, and ischemia, thereby preserving structural integrity and functional connectivity. This protective role is vital in maintaining cognitive function and preventing neurodegenerative processes. We examine how endocrine factors support neuronal resilience.