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Neuroprotection through Estrogen

Meaning

Neuroprotection through Estrogen describes the capacity of estrogenic compounds, both endogenous and exogenous, to shield neuronal tissues from various forms of injury, including oxidative stress, excitotoxicity, and ischemic damage. This protective effect extends beyond reproductive signaling, impacting synaptic plasticity and mitochondrial health within the central nervous system. Estrogen acts as a pleiotropic agent supporting neuronal survival pathways. It is a critical factor in maintaining long-term cognitive integrity, particularly during periods of hormonal fluctuation.