What is the Origin of Neuroprotection through Androgens?

This concept emerged from decades of research in neuroendocrinology, initially observing the high concentration of androgen receptors in brain regions critical for cognition and mood, such as the hippocampus and cortex. The therapeutic potential of androgens to protect against age-related neurodegeneration has driven modern clinical investigation in both male and female hormonal health. It links gonadal endocrine function directly to brain vitality.

What is the Mechanism of Neuroprotection through Androgens?

Androgens mediate neuroprotection through both genomic and non-genomic pathways. Genomically, the activated Androgen Receptor modulates the expression of genes involved in antioxidant defense, mitochondrial function, and neuronal growth factors. Non-genomically, androgens can rapidly activate intracellular signaling cascades, such as the PI3K/Akt pathway, which promotes cell survival and inhibits apoptotic signals. Furthermore, they help reduce neuroinflammation by dampening microglial activation.

Neuroprotection through Androgens

Meaning

Neuroprotection through Androgens describes the mechanism by which testosterone, dihydrotestosterone, and their metabolites exert beneficial, protective effects on neuronal structure, function, and survival within the central and peripheral nervous systems. These hormones are recognized for their capacity to mitigate neuronal damage from oxidative stress, reduce inflammation, and promote synaptic plasticity. This protective role is a key facet of hormonal health, influencing mood, cognitive reserve, and overall neurological resilience throughout the lifespan.