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Neuroprotection Signaling Cascades

Meaning

Neuroprotection Signaling Cascades are a series of interconnected intracellular biochemical events initiated in response to cellular stress or injury within the nervous system, ultimately leading to enhanced neuronal survival and functional preservation. These endogenous pathways represent the brain’s intrinsic defense mechanisms against excitotoxicity, oxidative stress, and inflammation, which are primary drivers of neurodegenerative processes. Therapeutic interventions often aim to potentiate or activate these cascades to maintain cognitive function and neural structural integrity over the lifespan. The strength of these signals is a direct reflection of neuronal resilience.