What is the Origin of Neuroprotection Hormones?

The recognition of this specialized function evolved from general endocrinology as researchers observed the profound effects of hormones like estrogen and progesterone on brain health, particularly following injury or during age-related decline. The term emphasizes a therapeutic, defensive role distinct from their classic reproductive or metabolic functions.

What is the Mechanism of Neuroprotection Hormones?

These hormones operate through multiple non-genomic and genomic pathways; they can act rapidly at the cell membrane to modulate ion channels and signaling cascades, or slowly via nuclear receptors to regulate the transcription of genes involved in anti-inflammatory and antioxidant defense. Key mechanisms include reducing microglial activation, promoting mitochondrial integrity, and stimulating the synthesis of Brain-Derived Neurotrophic Factor (BDNF).

Neuroprotection Hormones ∞ Area

Neuroprotection Hormones

Meaning

A category of endogenous steroid and peptide hormones that exhibit direct protective effects on the central and peripheral nervous systems, mitigating neuronal damage from oxidative stress, inflammation, and excitotoxicity. These hormones, which include certain sex steroids and neurotrophic factors, are crucial for maintaining brain structure, promoting synaptic health, and preserving cognitive function throughout the lifespan.