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Neuroplasticity Impairment

Meaning

Neuroplasticity impairment describes a pathological reduction in the brain’s intrinsic capacity to reorganize its structure, functions, and connections in response to experience, learning, or injury. This essential process, which involves synaptic pruning, synaptogenesis, and neurogenesis, is highly sensitive to hormonal fluctuations and metabolic health. In the context of hormonal wellness, chronic stress, severe hormonal deficiencies (e.g., estrogen or testosterone), or metabolic dysfunction can directly impair neuroplasticity, contributing to cognitive decline, mood disorders, and reduced resilience. Restoring hormonal balance is a clinical strategy to support and potentially reverse this impairment.