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Neuropeptide Signaling Cascades

Meaning

Neuropeptide Signaling Cascades refer to the complex, sequential activation of intracellular pathways initiated by the binding of small protein signaling molecules, known as neuropeptides, to their specific G-protein coupled receptors on neuronal or glial cell membranes. These peptides act as neuromodulators, often co-released with classical neurotransmitters, to profoundly influence mood, stress response, appetite, and social behavior. The cascades represent a slower, more sustained form of communication than traditional neurotransmission, leading to long-lasting changes in neuronal function and gene expression. Understanding these cascades is vital for addressing chronic psychological and physiological dysregulation.