What is the Origin of Neuronal Survival Pathways?

This terminology is derived from molecular neuroscience, describing the specific biochemical routes that signal a cell to live rather than undergo programmed cell death (apoptosis). Hormonal inputs are recognized as powerful upstream activators of these pro-survival cascades.

What is the Mechanism of Neuronal Survival Pathways?

Key survival mechanisms involve the upregulation of anti-apoptotic proteins like Bcl-2 and the activation of the PI3K/Akt pathway, which counters cellular stress signals. Steroid hormones, including progesterone metabolites, can directly engage these pathways by binding to specific nuclear receptors or membrane-bound sites. Robust activation of these pathways ensures that neurons can withstand physiological insults and maintain connectivity.

Neuronal Survival Pathways ∞ Area

Neuronal Survival Pathways

Meaning

Neuronal Survival Pathways are intracellular cascades activated to protect neurons from apoptotic signals, excitotoxicity, and oxidative damage, thereby promoting long-term viability within the central nervous system. Activation of these pathways is often influenced by neurotrophic factors and specific steroid hormones. Maintaining their function is critical for cognitive healthspan.