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Neuronal Scaffolding Integrity

Meaning

The structural soundness and functional robustness of the non-neuronal cellular matrix, primarily composed of glial cells and the extracellular matrix, that supports, protects, and regulates neuronal function within the central nervous system. This scaffolding is vital for synaptic plasticity, nutrient transport, and maintaining the blood-brain barrier. Its integrity is directly influenced by systemic inflammation and specific neurotrophic hormones.