What is the Origin of Neuronal Plasticity Loss?

Derived from neuroscience, this term describes the functional rigidity that supersedes the brain's inherent malleability, often seen as a hallmark of advanced aging or chronic neuroinflammatory states. It signifies a failure in the mechanisms responsible for synaptic remodeling and integration.

What is the Mechanism of Neuronal Plasticity Loss?

Loss of plasticity is often linked to altered expression of synaptic scaffolding proteins, reduced neurotrophic factor support from glial cells, and chronic exposure to inflammatory cytokines that impair long-term potentiation (LTP) mechanisms. Hormonal fluctuations, particularly those affecting sex steroids, can significantly modulate the maintenance of these critical, adaptable synaptic circuits.

Neuronal Plasticity Loss ∞ Area

Neuronal Plasticity Loss

Meaning

The diminished capacity of the central nervous system to reorganize synaptic connections, create new neural pathways, or adapt its structure and function in response to experience, learning, or recovery from localized injury. This signifies a loss of cerebral malleability.