A comprehensive, multi-system approach focused on preserving the structural integrity, functional connectivity, and metabolic efficiency of the central and peripheral nervous systems throughout the lifespan. This maintenance strategy encompasses protecting neurons from excitotoxicity and oxidative stress, supporting synaptic plasticity, and ensuring adequate cerebral blood flow. It is an essential component of longevity and performance protocols, directly supporting cognitive vitality and mood stability.
Origin
This concept stems from the fields of neuroscience, neuroendocrinology, and preventative medicine, recognizing that neuronal loss and dysfunction are central to age-related cognitive decline. The term emphasizes a proactive, continuous process of safeguarding the nervous system, moving beyond the traditional reactive treatment of overt neurological disease. Hormonal balance, particularly the role of neurosteroids, is a critical component of this maintenance.
Mechanism
Maintenance is achieved by supporting mitochondrial health within neurons, as these cells are highly energy-dependent. Key mechanisms include optimizing neurotrophic factor signaling, such as BDNF, which promotes synaptogenesis and neuronal survival. Additionally, interventions focus on reducing chronic neuroinflammation and ensuring the adequate provision of essential membrane lipids, thereby supporting the integrity of the neuronal cell structure and facilitating efficient signal transmission.
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