The electrical and chemical activity of neurons, encompassing action potential generation, synaptic transmission efficiency, and plasticity, all of which are critically regulated by the endocrine system. It is the basic operational status of the nervous tissue.
Origin
Rooted in classical neuroscience, its relevance here is magnified by the understanding that hormones act as essential modulators of neuronal excitability and connectivity. The concept acknowledges hormonal influence on neural substrate integrity.
Mechanism
Steroid hormones, such as progesterone and testosterone, directly interact with intracellular receptors in neurons to alter gene expression related to synaptic protein synthesis. Furthermore, pituitary hormones can influence glial cell function, which in turn supports optimal neuronal metabolic support and myelination.
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