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Neuronal Exosome Regulation

Meaning

Neuronal exosome regulation refers to the controlled process governing the biogenesis, cargo loading, and release of nanosized extracellular vesicles, known as exosomes, specifically secreted by neurons. These exosomes carry a diverse molecular payload, including lipids, proteins, and nucleic acids, and function as critical vehicles for intercellular communication, particularly between neurons and glial cells. Dysregulation of this process and the exosomal lipid cargo is implicated in the spread of pathological proteins and neurodegenerative disease progression.