Skip to main content

Neuronal Energy Substrates

Meaning

Neuronal Energy Substrates are the various molecules the brain and its constituent cells, including neurons and glia, utilize to generate adenosine triphosphate (ATP) for cellular maintenance and signaling. While glucose is the primary and obligate substrate, the brain possesses the metabolic flexibility to efficiently utilize alternative fuels, most notably ketone bodies and lactate, under specific physiological conditions. The availability and diversity of these substrates are crucial for sustained cognitive function and neuroprotection.