Neuronal Autophagy is the fundamental, highly regulated catabolic process by which neurons selectively degrade and recycle damaged cellular components, including aggregated proteins and dysfunctional mitochondria, to maintain axonal integrity This quality control mechanism is essential for neuronal survival, particularly in long-lived cells where accumulation of waste products can impair signaling Hormetic stressors, like controlled fasting, are known modulators of this essential housekeeping function.
Origin
Neuronal Autophagy is the fundamental, highly regulated catabolic process by which neurons selectively degrade and recycle damaged cellular components, including aggregated proteins and dysfunctional mitochondria, to maintain axonal integrity This quality control mechanism is essential for neuronal survival, particularly in long-lived cells where accumulation of waste products can impair signaling Hormetic stressors, like controlled fasting, are known modulators of this essential housekeeping function.
Mechanism
Neuronal Autophagy is the fundamental, highly regulated catabolic process by which neurons selectively degrade and recycle damaged cellular components, including aggregated proteins and dysfunctional mitochondria, to maintain axonal integrity This quality control mechanism is essential for neuronal survival, particularly in long-lived cells where accumulation of waste products can impair signaling Hormetic stressors, like controlled fasting, are known modulators of this essential housekeeping function.
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