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Neuromuscular Androgen Receptor

Meaning

The Neuromuscular Androgen Receptor (AR) refers to the population of androgen receptors expressed in both skeletal muscle fibers and the motor neurons that innervate them, mediating the profound anabolic and trophic effects of androgens on the musculoskeletal system. This receptor is a ligand-activated transcription factor that, upon binding testosterone or dihydrotestosterone (DHT), regulates the expression of genes crucial for muscle protein synthesis, satellite cell activation, and neuromuscular junction integrity. Its functional density and sensitivity are key determinants of muscle strength, mass, and recovery capacity. Variations in its expression are critical to understanding differential responses to androgen therapy.