What is the Origin of Neuromodulatory Agents?

A term from neuroscience and pharmacology, combining 'neuro' (relating to nerves) with 'modulatory' (having the ability to influence or modify). The distinction lies in their slow, diffuse, and long-lasting effects compared to fast, point-to-point neurotransmission.

What is the Mechanism of Neuromodulatory Agents?

Unlike classical neurotransmitters, neuromodulatory agents often bind to G-protein coupled receptors, initiating second messenger cascades that alter the properties of voltage-gated ion channels or modify the synthesis of other neurotransmitters. For example, hormones like oxytocin and vasopressin act as neuromodulators, altering social behavior and stress responses by changing the sensitivity of neural circuits over a broader temporal and spatial scale.

Neuromodulatory Agents

Meaning

Neuromodulatory Agents are a diverse class of substances, including hormones, neuropeptides, and pharmaceutical compounds, that influence the activity of neurons by affecting the overall state of the neuronal membrane, synaptic efficacy, or gene expression, rather than acting as direct excitatory or inhibitory neurotransmitters. These agents fine-tune the communication networks of the brain, regulating mood, arousal, sleep, and hormonal release patterns. Their clinical use is to restore optimal central nervous system function.

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Neuromodulatory Agents

Meaning

Origin

Mechanism

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