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Neuromodulator Fidelity

Meaning

Neuromodulator Fidelity is a measure of the precision and reliability of the signaling process mediated by neuromodulators within the central nervous system. High fidelity implies that the neuromodulator is synthesized, released, binds to its target receptor, and is subsequently cleared with optimal accuracy and timing, ensuring a clear and appropriate signal transmission. Conversely, low fidelity suggests impaired synthesis, excessive degradation, or receptor desensitization, leading to a distorted or ineffective neural message. This concept is critical for understanding the subtle dysfunctions underlying mood disorders and cognitive impairment where the overall level of a chemical may be less important than the quality of its signal.