Neurological Waste Clearance

Meaning

Neurological waste clearance is the vital physiological process by which metabolic byproducts, misfolded proteins, and excess neurotransmitters are efficiently removed from the central nervous system, particularly the brain. The primary system responsible is the glymphatic system, which functions most actively during sleep. Efficient clearance is essential for maintaining synaptic health, preventing neuroinflammation, and supporting optimal cognitive function. Impaired clearance is clinically associated with the accumulation of neurotoxic aggregates, a hallmark of several neurodegenerative conditions.

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