A therapeutic and lifestyle approach focused on sustaining the optimal function, structural integrity, and regenerative capacity of the central and peripheral nervous systems throughout the lifespan. This maintenance involves strategies to protect neurons from degeneration, enhance synaptic plasticity, and ensure robust neurotransmitter production. It is a proactive effort to preserve cognitive and motor function.
Origin
The concept arises from the intersection of neuroscience, gerontology, and endocrinology, acknowledging that neurological decline is a multifactorial process involving oxidative stress, inflammation, and hormonal shifts. The term emphasizes the dynamic, maintainable nature of the nervous system. Clinical interventions are often based on enhancing neurotrophic factor signaling.
Mechanism
Maintenance is achieved by optimizing factors that support mitochondrial health in neurons and reduce chronic neuroinflammation, often through targeted nutritional and hormonal support. Key hormones, including thyroid and sex steroids, directly influence myelin sheath integrity and dendritic branching. Furthermore, stimulating the release of Brain-Derived Neurotrophic Factor (BDNF) is a core mechanism for promoting neurogenesis and synaptic resilience.
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