The inherent biological processes within the central and peripheral nervous systems responsible for maintaining neuronal integrity, restoring function after injury, and clearing cellular debris and misfolded proteins. These mechanisms encompass neurogenesis, synaptic remodeling, and the protective actions of glial cells and neurotrophic factors. Hormonal signaling, particularly from sex steroids and growth factors, plays a critical modulatory role in their efficacy.
Origin
This field of study is rooted in neurobiology and regenerative medicine, focusing on the brain’s intrinsic capacity for plasticity and self-healing. Research into neurodegenerative diseases and trauma has elucidated the molecular pathways governing these restorative processes.
Mechanism
Repair involves several coordinated pathways, including the activation of brain-derived neurotrophic factor (BDNF) signaling, which promotes the survival and differentiation of new neurons. Microglia are essential for phagocytizing damaged cells, while the production of anti-inflammatory cytokines limits secondary injury. The efficacy of these mechanisms is profoundly influenced by the systemic hormonal environment, with hormones like progesterone and testosterone exhibiting direct neuroprotective properties.
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