A composite, quantitative measure designed to assess the overall efficiency, speed, and resilience of an individual’s central nervous system function across multiple cognitive domains. This index integrates objective data from psychometric testing, neuroimaging, and relevant physiological biomarkers, such as neurotransmitter levels and inflammatory markers, into a single, clinically actionable score. It serves as a comprehensive benchmark for evaluating the effectiveness of neuro-optimization and hormonal health protocols.
Origin
The Neurological Performance Index is a translational tool developed within performance and longevity medicine to standardize the measurement of cognitive health, moving beyond subjective self-reports. It is based on established neuropsychological assessment batteries but is enhanced by incorporating molecular and physiological data that reflect the underlying biological substrate of cognition. The index is a means of tracking progress in a data-driven clinical setting.
Mechanism
The calculation of the index mechanistically reflects the integration of several physiological parameters: processing speed is assessed through reaction time tests, which rely on efficient synaptic transmission; executive function is correlated with prefrontal cortex health and dopamine levels; and memory capacity is linked to hippocampal volume and BDNF expression. By combining these metrics, the index provides a holistic view of the neuro-endocrine system’s operational status and its capacity for sustained high-level function.
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