What is the Origin of Neurokinin B Signaling?

The term is derived from the neuropeptide Neurokinin B, a member of the tachykinin family, combined with 'signaling,' denoting the biochemical communication process. The clinical importance of this pathway was significantly advanced by the discovery of its pivotal role in the pathophysiology of menopausal vasomotor symptoms.

What is the Mechanism of Neurokinin B Signaling?

NKB is co-expressed with other neuropeptides in KNDy neurons located in the arcuate nucleus of the hypothalamus. NKB acts as an excitatory signal, driving the synchronized firing of these neurons to ensure the necessary pulsatile release of GnRH into the pituitary portal circulation. In the estrogen-deficient state of menopause, NKB signaling becomes dramatically overactive, which is thought to destabilize the hypothalamic thermoregulatory center, thereby triggering the characteristic hot flashes.

Neurokinin B Signaling ∞ Area

Neurokinin B Signaling

Meaning

Neurokinin B (NKB) Signaling describes the crucial neuropeptide communication pathway within the hypothalamic Kisspeptin-Neurokinin B-Dynorphin (KNDy) neuronal network. This signaling system, involving the peptide NKB and its receptor NK3R, acts as the central pulse generator for the reproductive axis. Its primary physiological function is to regulate the pulsatile release of Gonadotropin-Releasing Hormone (GnRH), which is indispensable for normal fertility and sex hormone production.