What is the Origin of Neuroinflammatory Attenuation?

This term is derived from neuroimmunology, combining the target system "Neuroinflammatory" (inflammation in the nervous system) with the therapeutic goal of "Attenuation" (reduction in force, effect, or value). It highlights the recognition of inflammation as a key driver of brain aging.

What is the Mechanism of Neuroinflammatory Attenuation?

Attenuation is achieved by modulating the activity of resident immune cells, the microglia, shifting them from a pro-inflammatory M1 phenotype to a protective M2 phenotype. This involves leveraging the anti-inflammatory properties of specific hormones, such as estrogen and glucocorticoids, and targeted nutraceuticals that inhibit NF-kappaB signaling. Reducing the release of cytokines like Interleukin-6 and Tumor Necrosis Factor-alpha helps to stabilize the blood-brain barrier and restore a neurotrophic environment.

Neuroinflammatory Attenuation ∞ Area

Neuroinflammatory Attenuation

Meaning

A clinical objective focused on reducing the chronic, low-grade inflammatory response within the central nervous system, which is characterized by sustained activation of microglia and astrocytes and the persistent release of pro-inflammatory cytokines. Attenuation aims to quiet this detrimental immune signaling, thereby protecting neurons and synaptic integrity from immune-mediated damage. This is a crucial strategy for maintaining cognitive function and preventing neurodegeneration.